Data for targeted metabolomics of hemoglobin peptides of PPQ- and ATQ-treated parasites.

3D7 trophozoites were treated for 2.5 h with 140 nM PPQ or 10 nM ATQ and the log2 fold changes for PPQ/no drug and ATQ/no drug are listed for three and six independent biological replicates, respectively. Data for this targeted approach is collected in negative mode and uses a retention-time-validated reference set of 115 targeted metabolites [46]. Only in N-carbamoyl-L-aspartate and dihydroorotate under ATQ treatment were significantly upregulated, as expected from previous studies [46]. The combined average log2 of PPQ/no drug and ATQ/no drug and the -log10(p-value) of all samples were plotted in S6C and S6D Fig. (XLSX)