GNPS - Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.) mediated neuroprotection in a rotenone-induced cellular model of Parkinsons disease

In the present study we carried out global and targeted metabolomics of differentiated IMR32 cells to study the neuroprotective mechanism of Yashtimadhu (Glycyrrhiza glabra L.) in rotenone induced cellular model of parkinsons disease. Our mass spectrometry data highlighted 2403 and 2934 aligned metabolites from the positive and negative modes respectively. Among the aligned metabolites, 756 metabolites from positive and 731 metabolites from negative polarity, were mapped to a known metabolite, and the others remained unassigned. A total of 1,102 non-redundant metabolites from the positive and negative modes were assigned.