Acquired tissue-specific promoter bivalency is a basis for PRC2 necessity in adult somatic cells
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
To define H3K27me3 modified genes in intestinal stem, progenitor and epithelial cells, we performed chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-Seq).We used RNA-sequencing to profile gene expression changes during intestinal stem cell differentiation into mature villus cells, as well as genes perturbed upon loss of PRC2 activity (deletion of Eed) . We find thousands of genes that change in expression including many H3K27me3 marked genes. The deregulated genes reaveal a intestinal tissue specific role of PRC2.
提供机构：
Dana Farber Cancer Institute
创建时间：
2022-02-20
