Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=251673ad22d830665f48cb54ba85ef19
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资源简介：
The small intestine has a robust regenerative capacity, and various cell types serve as âcells-of-originâ in the epithelial regeneration process after injury. However, how much each population contributes to regeneration remains unclear. Using lineage tracing, we found that Lgr5-expressing cellsâ derivatives contained radioresistant ISCs crucial for epithelial regeneration in the damaged intestine after radiation. Single-cell RNA sequencing analysis of Lgr5-derivatives identified primary source of epithelial regeneration in the irradiation damaged intetsine.
提供机构：
Medical Research Institute, Tokyo Medical and Dental University (TMDU)
创建时间：
2022-02-20
