Mediation analysis on effect of INR-variability on the increased risks of major adverse cardiovascular events and major bleeding complications in patients with chronic kidney disease in a nested case-control study.

Model 1 includes age, gender, hypertension, the use of platelet-inhibitors, diabetes mellitus and congestive heart failure.
Model 2 includes model 1 + INR VAR entire treatment period, Model 3 includes model 1 + INR variability over six months prior to event.
Model 4 includes model 1 + INR variability over three months prior to event.
Abbreviations: CKD  =  chronic kidney disease, MACE  =  major adverse cardiovascular event, OR  =  odds ratio, TIA  =  transient ischemic attack.