Mediation analysis on effect of INR-variability on the increased risks of major adverse cardiovascular events and major bleeding complications in patients with chronic kidney disease in a nested case-control study.

Model 1 includes age, gender, hypertension, the use of platelet-inhibitors, diabetes mellitus and congestive heart failure. Model 2 includes model 1 + INR VAR entire treatment period, Model 3 includes model 1 + INR variability over six months prior to event. Model 4 includes model 1 + INR variability over three months prior to event. Abbreviations: CKD = chronic kidney disease, MACE = major adverse cardiovascular event, OR = odds ratio, TIA = transient ischemic attack.