miRNA Expression from Cerebrospinal Fluid (CSF) from Prodromal Huntington Disease Patients

Analysis of microRNA (miRNA) expression in CSF from prodromal Huntington disease patients. Overall design: miRNA levels were measured in CSF from 60 PREDICT-HD study participants using the HTG protocol. Using a CAG–Age Product score, 30 prodromal HD participants were selected based on estimated probability of imminent clinical diagnosis of HD (i.e., low, medium, high; n = 10/group). For comparison, participants already diagnosed (n = 15) and healthy controls (n = 15) were also selected.