Figure S1 - Antibodies against the Envelope Glycoprotein Promote Infectivity of Immature Dengue Virus Serotype 2

Effect of mAbs on the infectious properties of standard DENV preparations. (A–G) P388D1 cells were infected with DENV-2 strain 16681 at MOG 1000 in the presence or absence of different anti-E mAbs. At 43 hpi supernatant was harvested and virus production was analyzed by plaque assay on BHK21-15 cells. Data are expressed as means of at least two independent experiments. St virus in the absence of antibodies was used as a control in all experiments (n = 6), for clarity the average of these results are only plotted in panel A. The error bars represent standard deviations (SD). Two-tailed Student's t-tests were used to determine significance; *, P<0.01.
(EPS)