Nitric Oxide does inversely affect endothelial shear- and gravity-responses.

Representative ECIS measurements on confluent HUVEC monolayers treated with the nitric oxide blocker L-NMMA (grey curves) compared to controls (black curves) that were subjected to an interval of A) hyper-gravity (2g) or B) fluid hear stress (8 dyn/cm2). Dot-plots present quantifications of the absolute, maximal change in resistance with and without the addition of L-NMMA. Statistical differences have been calculated by unpaired student’s t-test.