Total Synthesis of the Melodinus Alkaloid (±)-Melohemsine K
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The first total synthesis of the novel Melodinus alkaloid melohemsine K is described in five steps from known precursors. The key reaction of the synthesis is a tandem enamine formation/retro-aza-Michael reaction/Diels–Alder cycloaddition/intramolecular lactamization reaction cascade between indole-fused azepine and aldehyde precursors, forging the critical CDE tricyclic system. The synthesis provided a general approach to novel Melodinus alkaloids.
创建时间：
2025-04-25
