Single-cell profiling reveals pathogenic role and differentiation trajectory of Granzyme K+ tissue resident memory CD8+T cells in primary Sjögren’s syndrome

This study was conducted to depict the immune landscape of primary Sjögren’s syndrome (pSS) and to explore the pathogenic role of CD8+T cell subsets. single-cell RNA sequencing (including Gene expression, TCR and BCR) for labial glands (LG) and peripheral blood mononuclear cells (PBMC) from pSS patients (n = 3) and PBMC from age-/gender- matched healthy control (n = 4). *************************************************************** The raw data have been deposited into the CNGB Sequence Archive (CNSA) of the China National GeneBank DataBase (CNGBdb) with accession number CNP0003733 for controlled access to the personally identifiable sequence data. ***************************************************************