five

Replication timing of control and siRNA PR-set7 cells

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE69083
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资源简介:
Although histone modifications have been implicated in many DNA-dependent processes, their precise role in DNA replication remains poorly understood. Here, we show that the regulation of histone H4-K20 methylation states, in particular for the monomethylation, is a critical determinant of licensing and time activation of replication origins in mammalian cells. Two experimental condition : shRNA LUC cells (control) versus siRNA Prset-7 cells
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2016-07-02
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