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Diastereoselective Synthesis of 1,3,5-Trisubstituted 4-Nitropyrrolidin-2-ones via a Nitro-Mannich/Lactamization Cascade

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Figshare2016-02-22 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Diastereoselective_Synthesis_of_1_3_5_Trisubstituted_4_Nitropyrrolidin_2_ones_via_a_Nitro_Mannich_Lactamization_Cascade/2570788
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A versatile one-pot nitro-Mannich/lactamization cascade for the direct synthesis of 1,3,5-trisubstituted 4-nitropyrrolidin-2-ones has been developed. The reaction is easy to perform and broad in scope, and high levels of diastereoselectivity can be achieved.
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2016-02-22
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