Bruton's tyrosine kinase in complex with covalent inhibitor compound 25

Bruton's tyrosine kinase in complex with covalent inhibitor compound 25 Descriptor: N-methyl-N-[(1S,3r)-3-methyl-3-{[(6M,8S)-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}cyclobutyl]propanamide, Tyrosine-protein kinase BTK Authors: Metrick, C.M. Deposit date: 2023-08-15 Release date: 2024-06-26 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis. J.Med.Chem., 67, 2024