Concentration control coefficient of KorAdimers for each parameter of the models.

koff1, koff2, koff3, koff4– KorA, KorB dissociation rates, KorA for KorA-DNA complex, KorB from KorB-DNA complex, KorA from KorA-KorB-DNA complex and KorB from KorA-KorB-DNA complex, respectively, kA, kB – maximal KorA and KorB synthesis rates, kp – plasmid replication rate, πX, πY- scaling parameters for the protein synthesis, konD – protein association rate to the DNA, konP – protein dimerization rate. Smaller control coefficient implies greater robustness; model descriptions in Figure 1b. Note that the models have similar robustness for the majority of parameters; this includes the parameters governing protein synthesis and protein-DNA affinity and cooperativity. The one exception is the plasmid replication rate; the systems with two regulators are more robust than the systems with zero or one regulator.