X-ray Structure of SARS-CoV-2 main protease bound to GRL-024-20 at 1.45 A

X-ray Structure of SARS-CoV-2 main protease bound to GRL-024-20 at 1.45 A Descriptor: 3C-like proteinase, N-[(2S)-1-({(1S,2S)-1-(1,3-benzothiazol-2-yl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide Authors: Anson, B, Ghosh, A.K, Mesecar, A, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2020-07-10 Release date: 2020-08-19 Last modified: 2026-04-22 Method: X-RAY DIFFRACTION (1.45 Å) Cite: A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nat Commun, 12, 2021