The Cambridge Cohort of Open Spina Bifida

The dataset comprises nine reviews of 117 consecutive infants (50 male) born in 1963-1971 with open spina bifida and treated unselectively within 48 hours of birth at Addenbrooke’s Hospital, Cambridge, UK. The earlier reviews were conducted at home and school at the mean ages of 4 and 9 years and included clinical examination. Later reviews were based mainly on questionnaires (completed by patients and/or carers) and clinical records. The Office for National Statistics provided information on deaths to August 2017. The cohort is unique in having information from detailed neurological examination at birth and 99% follow up to the mean age of 50 years.<br><br>Selected publications from this dataset can be found in the 'References' section below. A full reference list with further publications from this work can be found in the README file included in the data package. <br><br>This is an anonymised version of this dataset. Dates of birth of cases (who were all born in 1963-1971) are available from the investigators, subject to appropriate approvals.本数据集包含1963年至1971年间出生的117名连续纳入的脊柱裂（spina bifida）患儿（其中男性50名）的9项随访评估记录，所有患儿均在英国剑桥阿登布鲁克医院于出生后48小时内接受了非选择性治疗。早期随访评估分别于平均年龄4岁和9岁时在家庭与学校开展，涵盖临床检查环节。后续随访评估主要基于患儿及/或照料者填写的问卷与临床病历开展。英国国家统计局（Office for National Statistics）提供了截至2017年8月的死亡相关随访信息。该队列的独特性在于，其包含患儿出生时的详细神经系统检查结果，且99%的研究对象被随访至平均50岁年龄。<br><br>本数据集的相关已发表文献可参见下文的“参考文献”部分。完整参考文献列表及本研究的更多相关出版物可在数据包附带的README文件中获取。<br><br>本数据集为匿名化版本。所有研究对象均出生于1963年至1971年，其出生日期信息需经适当审批后，可向研究团队申请获取。