Age-associated DNA methylation changes in Xenopus frogs

Here we present clear patterns of age-associated changes in DNA methylation in the aquatic vetebrate species Xenopus tropicalis. We generated nine whole-genome bisulfite sequencing (WGBS) datasets from three distinct age groups (young, approx. 1 year old; mature, approx. 5 years old; old, approx. 9 years old) to characterize the gene- and chromosome-scale changes. We have generated whole genome bisulfite sequencing (WGBS) profiles in nine Xenopus tropicalis samples representing young, mature and old adults to study how DNA methylation relates to aging in frogs.