Prophylactic efficacy and sensitivity to incomplete adherence.

The table shows the prophylactic efficacy (% reduction in infection probability) of all investigated drugs at their respective maximum achievable drug concentrations after chronic oral administration of the standard regimen and its efficacy at a concentration level that would be reached if the last dose had been taken least three days prior to virus exposure , with ke = ln(2)/t1/2 and halflifes t1/2 reported in Table 2. The 5-95% range of these estimates are shown in brackets and consider uncertainty in pharmacodynamic parameters IC50, m and variability in virus exposure after homosexual contact, according to the ‘virus exposure model’ (Methods section and Duwal et al. [18]. The last two columns show the EC50 and EC90 in the case when an individual was exposed to a single virus . MVC -maraviroc, EFV -efavirenz, NVP -nevirapine, DLV -delavirdine, ETR -etravirine, RPV -rilpivirine, RAL -raltegravir, EVG -elvitegravir, DTG -dolutegravir, ATV -atazanavir, APV -amprenavir, DRV -darunavir, IDV -indinavir, LPV -lopinavir, NFV -nelfinavir, SQV -saquinavir, TPV -tipranavir. *currently investigated for PrEP.