Total Synthesis of (±)-Eucophylline. A Free-Radical Approach to the Synthesis of the Azabicyclo[3.3.1]nonane Skeleton
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https://figshare.com/articles/dataset/Total_Synthesis_of_Eucophylline_A_Free_Radical_Approach_to_the_Synthesis_of_the_Azabicyclo_3_3_1_nonane_Skeleton/2130427
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资源简介：
The first total synthesis
of eucophylline was reported in 10 steps
and 10% overall yield. The naphthyridine core of eucophylline was
prepared through the coupling between a strained azabicyclo[3.3.1]nonan-2-one
and a trisubstituted benzonitrile, followed by a cyclization of the
corresponding amidine. This coupling reaction was shown to proceed
through a stable bicyclic chloroenamine intermediate. The azabicyclo[3.3.1]nonan-2-one
skeleton was in turn accessible through a straightforward sequence
including a free-radical three-component olefin carbo-oximation as
a key step.
创建时间：
2016-02-13
