The impact of HnRNPF knockdown on gene expression in MDA-MB-231 cell line

We discovered that HnRNPF is significantly upregulated in breast cancer tissues and is closely associated with the cell proliferation signaling pathway. Overexpression of HnRNPF notably inhibits cell proliferation in MDA-MB-231 breast cancer cells. HnRNPF promotes the expression of the cell cycle inhibitor p21. To explore the impact of HnRNPF on gene expression in MDA-MB-231 cells, we knocked down the expression of HnRNPF by siRNA and performed transcriptome analysis.