File S1 - Pentose Phosphate Pathway Function Affects Tolerance to the G-Quadruplex Binder TMPyP4

Figure S1: Fitness of yeast strain deletion library after treatment with TMPyP4, H202, HU and RHPS4. Fitness of yeast deletions strains after treatment with A) TMPyP4, B) H202, C) HU and d) RHPS4. Data is plotted as in Figure 2C and using data from Tables S4, S6, S7 and S8. All strains were cultured in parallel from the same initial starter cultures. Tables are also available for download from http://research.ncl.ac.uk/qfa/AndrewGQuad. Table S1. Strains of Saccharomyces cerevisiae used in this study. Table S2. GO analysis of 19 null mutations which increase TMPyP4 sensitivity. Table S3. Gene deletion strains with differential sensitivity to both TMPyP4 and H2O2. Table S4. TMPyP4 Screen 1. Table S5. TMPyP4 Screen 2. Table S6. H2O2 Screen. Table S7. RHPS4 Screen. Table S8. HU Screen. (PDF)