Gene expression profiling in mice with the depletion of prolyl hydroxylase domain proteins in endothelial cells

To evaluate gene expression changes in response to prolyl hydroxylase domain protein 2 and 3 (PHD2/3) depletion in endothelial cells, we performed mRNA-sequencing analysis with heart samples isolated from PHD2/3 endothelial knockout mice and their littermate control wild type mice. Overall design: Whole hearts were collected from the PHD2/3 endothelial knockout mice and their littermate control wild type mice at P12.