RNA analysis of the circadian rhythm of choroidal neovascularization

Many diseases that affect the heart, brain, and even the eyes originate from vascular pathology, emphasizing the role of vascular regulation. In age-related macular degeneration (AMD), excessive growth of abnormal blood vessels in the eye (choroidal neovascularization) ultimately leads to detachment of retinal pigment epithelium and decreased vision, indicating the importance of choroidal neovascularization in the treatment of age-related diseases. The circadian clock in the mammalian retina regulates various retinal functions, enabling the retina to adapt to the light dark cycle. Emerging evidence suggests a link between circadian clock and retinopathy, but the causal relationship has not yet been determined. Overall design: In this study, we investigated the regulatory mechanism of ceRNAs in the formation of choroidal neovascularization based on the different light dark cycles of the retina, choroid, and sclera in a mouse model of RPE.