Bovine Glycomacropeptide promotes the growth of Bifidobacterium longum subsp. infantis and modulates its gene expression

Microarray analysis of gene transcription in B. infantis following exposure to Glycomacropeptide (GMP) revealed a substantial transcriptional response to GMP relative to untreated bacteria or bacteria treated with periodate denatured GMP-P, with a greater number of differentially expressed transcripts and larger fold changes versus the control. The pool of differentially expressed transcripts included two glycoside hydrolase (family 25) genes, which were substantially up-regulated following exposure to GMP but not GMP-P. 9 samples were analysed comprising 3 biological replicates for each of 3 treatment conditions