Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity
收藏NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE190111
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资源简介：
Single cell sequence (SC-seq) has been used to explore the effect of IL10/CSF1R fusion protein modulation in tumor microenvironment. Four groups were analyzed which contain Ctrl, CSF1R, IL10 and BF10. MTC-Q1 oral cancer cells were orthotopic injection in C57BL/6 mice. CD45+ immune cells has been isolated, analyzed and sequenced by dropped based scRNA-seq, cDNA were sequenced by Illumina Novaseq 6000. Examination of therapeutic modulation of IL10/CSF1R fusion protein within tumor microenvironment in mice cancer model. SC-seq of CD45+ immune infiltrated cells from orthotopic cancer tissue after four dose treatments.
创建时间：
2023-09-14
