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Roles of Diclofenac and Its Metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice

NIAID Data Ecosystem2026-04-25 收录

代谢毒理学

转基因小鼠模型

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP219460 数据链接链接失效反馈

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资源简介：

Hepatic transcriptome analysis of TgCYP3A4/hPXR-humanized mice after treatment with Diclofenac and its metabolites

应用场景：

创建时间：

2019-12-05

转基因小鼠模型

星形胶质细胞

The Khakh laboratory developed and characterized a new Aldh1l1-Cre/ERT2 transgenic mouse line to selectively target astrocytes in vivo. Crosses with RiboTag mice allowed sequencing of actively transla

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RNA-seq of iNKT cells in the skin and spleen of CCR10+/EGFP mice

免疫细胞转录组学

转基因小鼠模型

To compare transcriptomic profiles between skin and spleen iNKT cells, the analysis of global gene expressions in iNKT cells was performed using RNA-seq data obtained from iNKT cells purified from ski

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Developmental Exposure to 2,2’,4,4’-Tetrabromodiphenyl Ether Permanently Alters Blood-Liver Balance of Lipids in Male Mice. Developmental Exposure to 2,2’,4,4’-Tetrabromodiphenyl Ether Permanently Alters Blood-Liver Balance of Lipids in Male Mice

代谢毒理学

非酒精性脂肪肝病

Polybrominated diphenyl ethers (PBDEs) were used as flame-retardant additives starting 1965 and were recently withdrawn from commerce in North America and Europe. Approximately 1/5 of the total U.S. p

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Proportion of mice with NPY ectopic expression among Tg2576 mice and NTg littermates.

神经肽Y表达

转基因小鼠模型

Data represent the number of animals with NPY ectopic expression in mossy fibers compared to the total number of animals in each group. Note that only Tg2576 mice present aberrant NPY expression. Prop

NIAID Data Ecosystem50

Additional file 8: of Stoichiometric gene-to-reaction associations enhance model-driven analysis performance: Metabolic response to chronic exposure to Aldrin in prostate cancer

代谢网络建模

代谢毒理学

Results of the analyses comparing predictive capabilities of GPR-based and S-GPR-based approaches using iMat, Gimme, GonĂ§alves et al. 2012 and MADE algorithms. (XLSX 309 kb)

Figshare2019-08-16 更新50

Roles of Diclofenac and Its Metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice

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