SNPs associated with primary insulin secretion traits at genome-wide significance levels.

The results are from the meta-analyses of the discovery GWAS, CardioMetabochip and de novo genotyping. Results are reported for the directly genotyped and imputed SNPs tested for association with insulin secretion measured as CIR and AUCIns/AUCGluc (trait abbreviations are listed in the Methods “Phenotype definition” section). Freq denotes the allele frequency of the insulin secretion-reducing allele. N = sample size. Since the index SNP rs933360 (A/G) from the discovery GWAS was not present on the CardioMetabochip platform, a variant (rs6943153 (C/T)) in strong LD with the former (r2 = 0.82) was used as a proxy SNP for the meta-analyses.