The LEDGIN GS-9822 inhibits HIV-2 infection and enhances HIV-2 latency.

NIAID Data Ecosystem2026-05-10 收录

HIV潜伏逆转

整合酶抑制剂研究

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https://www.ncbi.nlm.nih.gov/sra/SRP617932 数据链接链接失效反馈

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HIV-1 and HIV-2 integration sites obtained with increasing concentrations of the LEDGIN GS-9822.

创建时间：

2026-01-01

Potent and targeted activation of HIV-1 using the CRISPR/Cas9 activator Complex

HIV潜伏逆转

CRISPR基因激活

Integration of the HIV-1 provirus in the host genome ensures a persistent supply of latently infected cells. This latent reservoir is recalcitrant to antiretroviral therapy (ART) making lifelong treat

NIAID Data Ecosystem70

CD4+ T cell transcriptional reprogramming by small compounds

HIV潜伏逆转

转录重编程

A major obstacle for HIV eradication is the persistence of latent reservoirs, cells harboring replication competent yet transcriptionally silent proviruses. These reservoirs, composed primarily of CD4

NIAID Data Ecosystem50

PolyIC-coated Prussian blue nanoparticles as a dual-mode HIV latency reversing agent - Supplementary dataset

HIV潜伏逆转

纳米药物递送

Aim: To investigate Prussian blue nanoparticles (PBNPs) coated with the synthetic analog of dsRNA polyinosinic-polycytidylic acid (polyIC) for their ability to function as HIV latency reversing agents

DataCite Commons2024-05-16 更新30

A truncated HIV Tat demonstrates potent and specific latency reversal activity. A truncated HIV Tat demonstrates potent and specific latency reversal activity

HIV潜伏逆转

Tat蛋白再激活实验

The barrier to HIV-1 functional cure is caused by a small pool of latently infected resting CD4 T-cells that persist under antiretroviral therapy. Notably this latent reservoir of infected cells will

NIAID Data Ecosystem60

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

HIV潜伏逆转

药物临床试验

Pharmacologically-induced activation of replication competent proviruses from latency in the presence of antiretroviral treatment (ART) has been proposed as a step towards curing HIV-1 infection. Howe

NIAID Data Ecosystem40

The LEDGIN GS-9822 inhibits HIV-2 infection and enhances HIV-2 latency.

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