Interactive odds ratio estimation of mt-<i>ND3</i> rs2853826, <i>PGC1α</i> rs8192678, <i>UCP2</i> rs659366 genotypes in <i>SIRT1</i> rs12778366 genotype backgrounds.

P values and odds Ratios are estimated by binary logistic regression using age, gender, BMI and center of collection as covariates. NS = Not significant, NA = Not available *all risk genotypic combinations (mt-ND3 rs2853826 A, PGC1α rs8192678 XA, UCP2 rs659366 GG) were compared against all protective genotypic combinations (mt-ND3 rs2853826 G, PGC1α rs8192678 GG, UCP2 rs659366 XA). a = independent of SIRT1 background (n = 292) and in the background SIRT1 genotypes, b = TT (n = 185), c = TX (n = 276) d = CX (n = 107) e = empirical p values were estimated by logistic regression using PLINK adaptive permutations (maximum1,000,000 permutations).