Genome-wide microarray analysis to identify the differentially expressed patterns of lncRNAs of cholesteatoma tissues compared with matched normal skin tissues.

We performed genome-wide microarray analysis to identify the differentially expressed patterns of lncRNAs in cholesteatoma. Our data indicated that lncRNA expression profiles were significantly altered in cholesteatoma compared with normal skin tissues. A total of 787 lncRNAs were identified (fold change ≥2.0, P < 0.05), consisting of 181 upregulated and 606 downregulated lncRNAs. A genome-wide analysis was performed to profile differences in lncRNA expression between 4 paires of cholesteatoma and matched normal skin samples. Two female and 2 male patients aged 18-year-old to 32-year-old who underwent unilateral middle ear cholesteatoma surgerieswere enrolled in this study.