SP8 promotes an aggressive phenotype in hepatoblastoma via FGF8 activation

Purpose: Despite an overall good outcome of hepatoblastoma patients, prognosis is still poor if associated with metastatic disease. Transcriptomic profiling enables a global view on deregulated cellular pathways. The goal of this study was to compare RNAseq data of metastasized and non-metastasized specimens to identify new molecular players for high-risk hepatoblastoma patients. Overall design: Liver mRNA profiles of hepatoblastoma patients