Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases
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资源简介：
1.Identify inducers of OPC to OL differentiation through high-throughput screening based on MBP expression; 2. Multiple MEK inhibitors promote OPC to OL differentiation, indicating blockade of MAPK-ERK signaling is sufficient to induce OPC differentiation into OLs. 3. PD0325901 facilitates the formation of myelin sheaths in OPC-neuron co-culture in vitro. 4. PD0325901 promotes myelin regeneration in demyelination models.
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同济大学创建时间：
2021-09-08
