RNA sequencing of undifferentiated and differentiated SH SY5Y cells
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https://www.ncbi.nlm.nih.gov/sra/SRP238260
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资源简介：
DNA topoisomerase IIB has an important role in ligand mediated transcriptional regulation of gene expression. SH-SY5Y is a neuroblastoma cell line that can be induced to differentiate into neuronal-like cells in response to retinoic acid. In this study TOP2B has been knocked out using crispr-cas9 to determine the role of TOP2B in the transcriptional response to retinoic acid. RNA was prepared from untreated wild type and TOP2B null SH-SY5Y cells and from cells exposed to 10 uM All Trans Retinoic Acid (ATRA) for 24 hours. Overall design: 4 replicates of each of untreated WT, untreated TOP2B-/- , ATRA treated WT and ATRA treated TOP2B-/-
创建时间：
2022-11-30
