Stools from a human APOE2 donor reduces amyloid and tau pathology and increases neuroinflammation in a 3xTg AD mouse model

The microbiota of 15-month-old 3xTgAD mice was altered through fecal microbiota transplantation (FMT) from either a human APOE2 donor (e2-FMT) or a mouse donor (M-FMT). FMT was performed alone or in combination with antibiotics and a proton-pump inhibitor, following the Microbiota Transfer Therapy (MTT) protocol. E2-FMT but not M-FMT reduced AD pathology and increased neuroinflammation in mice, suggesting that the gut microbiota may be a mediator of the protective effect of APOE2.