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Gene expression analysis of in vivo-grown tumors treated with compounds that either de-bulk the tumor or target cancer stem cells

ChEBI2015-01-23 更新2026-07-21 收录

药物机制研究

癌症干细胞靶向治疗

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-49232 数据链接链接失效反馈

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资源简介：

Gene expression analysis of in vivo-grown tumors treated with compounds that either de-bulk the tumor or target cancer stem cells

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创建时间：

2015-01-23

无义突变通读

药物机制研究

The drug molecule PTC124 (Ataluren) has been described as a read-through agent, capable of suppressing premature termination codons (PTCs) and restoring functional protein production from genes disrup

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CDK4/6 inhibitors induce repication stress to cause long-term cell cycle withdrawal

细胞周期调控

药物机制研究

CDK4/6 inhibitors arrest the cell cycle in G1-phase. They are licenced to treat breast cancer and are also undergoing clinical trials against a range of other tumour types. To facilitate these efforts

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The IC 50 of the inhibitory effect of tylophora alkaloids on NF-κB, AP-1, and CRE signalging pathways in HepG2 and HEK-293 cells.

信号通路抑制

药物机制研究

Values are means ± SD of at least three experiments, with each data point done in triplicate. The IC50 concentrations of these compounds are significantly different (p<0.05) from each other in between

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Table_1_Doxycycline, an Inhibitor of Mitochondrial Biogenesis, Effectively Reduces Cancer Stem Cells (CSCs) in Early Breast Cancer Patients: A Clinical Pilot Study.DOCX

癌症干细胞靶向治疗

癌症药物干预

Background and objectives: Cancer stem cells (CSCs) have been implicated in tumor initiation, recurrence, metastatic spread and poor survival in multiple tumor types, breast cancers included. CSCs sel

NIAID Data Ecosystem60

Inhibition of C-terminal binding protein attenuates transcription factor 4 signaling to selectively target colon cancer stem cells

癌症干细胞靶向治疗

结直肠癌分子机制

Selective targeting of cancer stem cells (CSCs), implicated in tumor relapse, holds great promise in the treatment of colorectal cancer. Overexpression of C-terminal binding protein (CtBP), an NADH de

Figshare2016-01-19 更新40

Gene expression analysis of in vivo-grown tumors treated with compounds that either de-bulk the tumor or target cancer stem cells

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