aKlotho and sTGFBR2 treatment promotes endogenous cartilage regeneration and prevents osteoarthritis progression

Osteoarthritis (OA) is the most prevalent musculoskeletal disorder and the most common form of arthritis among the elderly. Despite recent basic biology and clinical progress, the understanding and treatment of this and other cartilage-associated diseases are still a challenge. By using an in vivo rat OA model and in vitro human studies we report the improved homeostasis and repairing capacity of two soluble molecules, aKlotho and sTGFBR2, that in combination are able to prevent the progression of OA and promote cartilage regeneration. Overall design: 2 WT, 3 disease, 3 disease untreated, and 2 disease treated samples were profiled by mRNA-seq to examine how global gene expression changes associated with disease progression and treatment effect.