Association of LDLR splice region variant rs72658867-A and intronic variant rs17248748-T with non-HDL-C in Denmark, Netherlands and Iran.

Shown are association results for rs72658867-A and rs17248748-T with non-HDL-C, TG and HDL-C in replication samples from Denmark, Netherlands and Iran.aAssociation results are adjusted for the variants rs17248748-T and rs6511720-T (r2 = 0.96 with rs17248720-T in Europeans in the 1000G Phase 3 data).bAssociation results are adjusted for the variants rs72658867-A and rs6511720-T (r2 = 0.96 with rs17248720-T in Europeans in the 1000G Phase 3 data).cAll replication samples combined for each trait.dReplication samples combined with Icelandic samples, # non-HDL-C = 139,385, # TG = 100,350, # HDL = 139,753.eEffect (β) in mmol/l given with respect to allele A for rs72658867 and allele T for rs17248748.fEffect (β) in % change is given with respect to the allele A for rs72658867 and allele T for rs17248748.gPhet = P-value for a test of heterogeneity in the combined effect estimate.Association of LDLR splice region variant rs72658867-A and intronic variant rs17248748-T with non-HDL-C in Denmark, Netherlands and Iran.