Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the () gene-5

embryos. B, C: photographs of wild type (B) and -/- (C) body walls, showing thinning and transparency in the mutant. D-I: Haematoxylin and Eosin stained sections of adult skin from wild type (D, G), +/- (E, H) and -/- (F, I) mice showing atrophy of subcutaneous muscles in +/- and -/- mice, with arrow heads marking the residual muscle layer. Histology of the subcutaneous adipose tissue in wild type (J) and -/- (K) showing large mature fat cells in the wild type in contrast to the mixture of large (mature) and small (immature) fat cells in the mutant. L, M: Haematoxylin and Eosin stained section of adult intercostal muscles in wild type (L) and -/- (M) mice showing muscle atrophy and transdifferentiation to fat in the mutant. Scale bars in A = 20 μm; D-F = 50 μm; G-M = 10 μm.<b>Copyright information:</b>Taken from "Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the () gene"http://www.biomedcentral.com/1471-213X/8/18BMC Developmental Biology 2008;8():18-18.Published online 20 Feb 2008PMCID:PMC2275724.