N-methyl-D-aspartate receptor antagonists, such as MK-801, phencyclidine, and ketamine, have been used to establish animal models of schizophrenia. We previously reported that a faster off-rate phosph
Population-based studies show cannabis use doubles the risk of developing schizophrenia especially when use occurs in early adolescence (prior to age 15). However, the cause-and-effect mechanisms are
This study investigates the role of TrkB in PV and SST interneurons and explores the validity of an interneuron-specific TrkB knockout mouse model. Mice with reduced TrkB expression in either PV-INs o
Administration of the noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist phencyclidine (PCP) to rodents is widely used as preclinical model for schizophrenia. Most studies on this model em
Contemporary rodent models for bipolar disorders split the bipolar spectrum into complimentary behavioral endophenotypes representing mania and depression. Widely accepted mania models typically utili
