Aberrant gene expression leakage from linage-specific heterochromatic loci during senescence

To understand induction of cornification genes on lineage appropriate (keratinocyte differentiation) and inappropriate (fibroblast senescence) conditions , we generated histone modification and gene expression dataset. Then we compared these keratinocyte's dataset with our previous fibroblast senescence dataset in the study. Overall design: Histone modification and mRNA profiles of proliferating and differentiated keratinocytes were generated.