Human Apoe3 and Apoe4 alleles have differential effects on mouse olfactory epithelium

Alzheimer's Disease (AD) is a progressive age-dependent disorder whose risk is determined in large part by genetic factors. We investigated the effects of human APOE3 and APOE4 alleles on the mouse olfactory epithelium. Overall design: Six biological replicates of Apoe4 and four biological replicates of Apoe3 were analyzed at six months aged mice