Single cell transcriptomic profiling of tau pathophysiology in a novel 3D neural-glial coculture model
收藏NIAID Data Ecosystem2026-05-01 收录
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资源简介：
We report the development of a novel 3D human induced pluipotent stem cell derived neural-glial coculture model of tauopathy and identify pathways associated with pathogenesis by 10X 3' V3 single cell RNA sequencing. Overall design: 3D human induced pluripotent stem cell derived neurons exposed to oligomeric tau and glial cells were co-cultured with and without PU-H71 drug treatment. 10X 3' V3 single-cell RNA sequencing was performed at 1, 2, and 3 week timepoints.
创建时间：
2023-03-31
