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The hemogenic competence of endothelial progenitors is restricted by Runx1 silencing during embryonic development

ChEBI2016-05-31 更新2026-07-12 收录

胚胎造血发育

Runx1转录因子

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-64377 数据链接链接失效反馈

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资源简介：

The hemogenic competence of endothelial progenitors is restricted by Runx1 silencing during embryonic development

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创建时间：

2016-05-31

胚胎造血发育

单细胞转录组学

We profile the transcriptional landscape of mouse fetal placenta and identify four distinct types of haematopoietic stem/progenitor cells (HSPCs) during mid-gestation using single-cell RNA sequencing.

NIAID Data Ecosystem70

RNA-Seq of sorted E10.5 and E11.5 AGM cell populations from Gata3-GFP embryos

胚胎造血发育

单细胞转录组学

The aim of this study was to examine the whole transcriptome of pools of 20 cells of Gata3-expressing AGM subpopulations (haematopoietic [HC], mesenchymal [MC], sympathetic nervous system [SNS], and e

NIAID Data Ecosystem20

Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo. Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo

胚胎造血发育

血管周细胞功能

Hematopoietic stem cells (HSCs) produce all essential cellular components of the blood. Stromal cell lines supporting HSCs follow a vascular smooth muscle cell (vSMC) differentiation pathway, suggesti

NIAID Data Ecosystem20

RUNX1 and the endothelial origin of blood

胚胎造血发育

生血内皮细胞转录组

The transcription factor RUNX1 is required in the embryo for formation of the adult hematopoietic system. Here we describe the seminal findings that led to the discovery of RUNX1 and of its critical r

NIAID Data Ecosystem60

A Sox17 downstream gene Rasip1 is involved in the hematopoietic activity of intra-aortic hematopoietic clusters in the midgestation mouse embryo. Mus musculus

胚胎造血发育

造血干细胞调控

Background: During mouse embryonic development, definitive hematopoiesis is first detected around embryonic day (E) 10.5 in the aorta-gonad-mesonephros (AGM) region. Hematopoietic stem cells (HSCs) ar

NIAID Data Ecosystem20

The hemogenic competence of endothelial progenitors is restricted by Runx1 silencing during embryonic development

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