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Loss of Oncogenic Notch1 Contributes to PI3 Kinase Inhibitor Resistance in T Lineage Leukemia

ChEBI2014-06-24 更新2026-07-21 收录

白血病耐药机制

靶向治疗研究

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-48260 数据链接链接失效反馈

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Loss of Oncogenic Notch1 Contributes to PI3 Kinase Inhibitor Resistance in T Lineage Leukemia

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创建时间：

2014-06-24

白血病耐药机制

RNAm6A修饰分析

N6-Methyladenosine (m6A) is the most abundant post-transcriptional modification in eukaryotes, the imbalance of which is reported to be associated with various pathological processes, including drug r

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Allele-specific gene regulation, phenotypes, and therapeutic vulnerabilities in estrogen receptor alpha mutant endometrial cancer (RNA-Seq)

癌症基因组数据

靶向治疗研究

Activating estrogen receptor alpha (ER) mutations are present in primary endometrial and metastatic breast cancers, promoting estrogen-independent activation of the receptor. Functional characterizati

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Data_Sheet_1_Acute Myeloid Leukemia Chemo-Resistance Is Mediated by E-selectin Receptor CD162 in Bone Marrow Niches.PDF

白血病耐药机制

肿瘤微环境靶向治疗

The interactions of leukemia cells with the bone marrow (BM) microenvironment is critical for disease progression and resistance to treatment. We have recently found that the vascular adhesion molecul

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Supplementary Table S1 from Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid Leukemia

白血病耐药机制

线粒体自噬功能筛选

Supplementary Table 1 shows the results of our CRISPRi screens.

Figshare2023-07-07 更新60

Crystal structure of the double mutant (D52N/L375F) of the full-length NT5C2 in the active state

白血病耐药机制

蛋白质结构解析

Crystal structure of the double mutant (D52N/L375F) of the full-length NT5C2 in the active state Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Cytosolic purine 5'-nucleotidase, ... Authors: F

Protein Data Bank Japan2023-10-11 更新50

Loss of Oncogenic Notch1 Contributes to PI3 Kinase Inhibitor Resistance in T Lineage Leukemia

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