OncotRF

OncotRF contains an analysis pipeline for tRF identification and characterization, analysis results of 11,211 small RNA sequencing samples and 8,776 RNA sequencing samples, and clinicopathologic annotation data from The Cancer Genome Atlas (TCGA). The results include: tRF identification and quantification across 33 cancers, abnormally expressed tRFs and genes, tRF-gene correlations, tRF-gene networks, survival analyses, and tRF-related functional enrichment analyses. Users are also able to identify differentially expressed tRFs, predict their functions, and assess the relevance of the tRF expression levels to the clinical outcome according to user-defined groups.OncotRF 包含一套用于tRNA衍生片段（transfer RNA-derived fragments, tRF）识别与表征的分析流程，涵盖11211例小RNA测序样本与8776例RNA测序样本的分析结果，以及来自癌症基因组图谱（The Cancer Genome Atlas, TCGA）的临床病理注释数据。其分析结果包含：33种癌症中的tRF识别与定量分析、异常表达的tRF与基因、tRF-基因相关性分析、tRF-基因网络、生存分析，以及tRF相关功能富集分析。用户还可根据自定义分组，识别差异表达的tRF、预测其功能，并评估tRF表达水平与临床结局的相关性。

搜集汇总

背景与挑战

背景概述

OncotRF是一个综合性数据库，专注于分析与癌症相关的转移RNA衍生RNA片段（tRFs）。它基于TCGA的大量测序样本，提供了tRFs的识别、定量、差异表达、功能注释及临床相关性分析等工具，旨在支持癌症生物标志物发现和机制研究。