We conducted mutation accumulation line experiments in N2 C. elegans, and two mitophagy deletion strains, dct-1 and pink-1. MA lines were conducted in control conditions, as well as on plates with 50u

NIAID Data Ecosystem30

DNA-seq of mitochondrial DNA from liver of OGG1 and MUTYH deficient mice that have been bred for five consecutive generations

线粒体DNA突变积累

碱基切除修复缺陷模型

Studying whether removal of base-excision repair from mitochondria will result into increase in mitochondrial DNA (mtDNA) mutation load. The endogenous genes of OGG1 and MUTYH DNA glycosylases were mo

NIAID Data Ecosystem00

Iron-depletion promotes mitophagy to maintain mitochondrial integrity in pathogenic yeast Candida glabrata

病原机制

线粒体自噬功能研究

Candida glabrata , a haploid budding yeast, is the cause of severe systemic infections in immune-compromised hosts. The amount of free iron supplied to C. glabrata cells during systemic i

Taylor & Francis Group2019-07-02 更新30

Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing.

线粒体DNA突变积累

组织特异性衰老研究

In 60 human tissue samples (encompassing skeletal muscle, heart and kidney) obtained from subjects aged from under 1 to 90 years, we used quantitative PCR procedures to quantify mitochondrial DNA (mtD

PubMed Central1998-03-01 更新00

Mus musculus strain:C57BL/6J Raw sequence reads

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