Overview of previous studies evaluating the role of lactoferrin and calprotectin in faeces in patients with Clostridium difficile infection.

*Disease was considered severe if any of the following was present: diarrhoea severe enough to produce clinical signs of volume depletion and to require hospitalization, WBC count of >10,000/ml, or temperature of >38.3°C.**Scoring system accounting for fever (>38°C), ileus (clinical or radiographic), systolic blood pressure (***Automatically classified as severe if age ≥65 years, WBC>15×109/L, stool ≥10 per day, not able to tolerate oral intake, usually abdominal complaints, radiographic or peritoneal signs, multiple comorbidities including but not limited to renal failure and immunosuppression.Overview of previous studies evaluating the role of lactoferrin and calprotectin in faeces in patients with Clostridium difficile infection.