Risk of colon cancer according to baseline quintiles of one-carbon nutrient intake by CIMP expression in tumors among 88,691 women in the Nurses' Health Study (1980–2002).

‡Age adjusted only.*All models are adjusted for age (continuous), energy intake, gender, screening sigmoidoscopy, family history of colorectal cancer, aspirin use, smoking, physical activity in METs, baseline body mass index, a history of colon polyps, beef intake, calcium, multi-vitamin use, and baseline folate, vitamin B6, B12, methionine, and alcohol if not primary exposure. P for heterogeneity of the association for folate intake and CIMP-low/0 colon cancer versus folate intake and CIMP-high colon cancers = 0.73 (χ2 = 1.31, 3 d.f.).P for heterogeneity of the association for vitamin B6 intake and CIMP-high colon cancer and vitamin B6 intake and CIMP-low/0 colon cancers = 0.63 (χ2 = 2.6, 4 d.f.) and for vitamin B12 intake = 0.94 (χ2 = 0.79, 4 d.f.). P for heterogeneity of the association for methionine intake and CIMP-high colon cancer and methionine intake and CIMP-low/0 colon cancers = 0.007 (χ2 = 14.097, 4 d.f.), and for alcohol intake = 0.32 (χ2 = 3.52, 3 d.f.).