MIcrobial composition of gastric lesions: Differences based on Helycobacter pylori

Globally Gastric Cancer (GC) ranks fourth for mortality. Helicobacter pylori (HP) infection is a major risk, with precursor lesions for the intestinal subtype in which severe gastric disease is dependent on virulence factors. However, colonization by other microorganisms may act as cofactors. In fact, RNA16S analysis revealed that the stomach harbors a distinct and complex ecosystem. However, in current metagenome studies, there isn't association with HP virulence. We aimed to investigate the difference in microbiota composition among gastric lesions, including GC, according to HP virulence (cagA, cagE).